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KMID : 0603820070130020099
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Journal of Experimental & Biomedical Science
2007 Volume.13 No. 2 p.99 ~ p.104
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Morphological Changes in Adipose and Liver Tissues by 17beta-estradiol in Female Ovariectomized C57BL/6J Mice
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Jeong Sun-Hyo
Choi Hyung-Kyu
Yoon Mi-Chung
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Abstract
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To determine whether 17beta-estradiol induces the morphological changes in adipose and liver tissues, we measured the effects of 17beta-estradiol on adipose tissue mass, adipocyte histology and hepatic lipid accumulation in female ovariectomized (OVX) C57BL/6J mice. Compared to vehicle-treated control mice, 17beta-estradiol-treated mice decreased adipose tissue mass and the size of adipocytes, and concomitantly increased the number of adipocytes in a dose-dependent manner. In addition, the administration of 17beta-estradiol resulted in reduced hepatic lipid accumulation in a dose-dependent manner. These results suggest that estrogen may regulate adipocyte development and lipid metabolism in female OVX C57BL/6J mice.
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KEYWORD
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Estrogen, Adipocyte development, Lipid metabolism, OVX female
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